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Ag source lab ellsworth iowa1/19/2024 ![]() Formation of the testicular cords (or seminiferous cords) is the first visual indication that the gonad is a testis. We have two projects one in the ovary and the other in the testis which are studying the regulation of angiogenic factors during ovarian or testicular embryonic differentiation.ġ) Role of angiogenic factors in morphological testis differentiation.ĭevelopment of the initial cellular structures that constitute a testis occurs during embryonic development. Most of these cases can be attributed to potential abnormal differentiation of cells during development of the embryonic or fetal testis. These men are infertile due to several different reasons from testicular cancer (increased incidence in men under 20 years of age) to low sperm count. For example, in the past twelve years there has been an increase in male infertility cases in several Industrialized Countries (including the US). Vascular Endothelial Growth Factor (VEGFA)Įarly Gonadal Development: The reason that we are studying early development of structures (follicles, vasculature and seminiferous cords) in the testis and ovary is that many causes of adult and potentially domestic livestock infertility can be traced back to abnormal cellular differentiation during gonadal development. Primarily, our laboratory is investigating a paracrine growth factor- Vascular Endothelial Growth Factor (VEGF) and its involvement in: 1) sex-specific vascular development during embryonic gonadal development 2) follicular maturation and 3) ovulation in the female and 4) its role in spermatogenesis. The Research Focus of the Cupp laboratory is to study the molecular and cellular regulators of gonadal development and function.
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